Tg(NEFL-cre)50Msd
Transgene Detail

Summary

• Symbol: Tg(NEFL-cre)50Msd
• Name: transgene insertion 50, Michael Sendtner
• MGI ID: MGI:3702327
• Synonyms: NF-L-Cre
• Transgene: Tg(NEFL-cre)50Msd Location: unknown
• Alliance: Tg(NEFL-cre)50Msd page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:77229
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(NEFL-cre)50Msd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  NEFL (4747)

  Nefl	(MGI:97313)

• Mutation details: 2kb of the human promoter and 3kb of downstream sequence were used to drive the expression of Cre in the brain and spinal cord. Two lines were created (lines 50 and 13) with only line 50 exhibiting expression. Crosses to a LacZ reporter strain was used to test the transgene insertion where by recombination resulted in neural LacZ expression. (J:77229)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	NEFL (human) Summary of all recombinase alleles driven by NEFL. Comparative matrix view of recombinase activities Alliance human NEFL gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77229 Schweizer U, et al., Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult. J Cell Biol. 2002 Jan 21;156(2):287-97
• All: 4 reference(s)