Tg(CAG-cat,-Notch1)1Ysa
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-Notch1)1Ysa
• Name: transgene insertion 1, Yumiko Saga
• MGI ID: MGI:3702441
• Synonyms: CAG-CAT-NICD1, Notch1^GOF, Tg(ACTB-cat,-Notch1)1Ysa
• Transgene: Tg(CAG-cat,-Notch1)1Ysa Location: unknown
• Alliance: Tg(CAG-cat,-Notch1)1Ysa page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: This transgene carries the Notch1 intracellular domain downstream of a chicken beta-actin promoter (CAG promoter) and a floxed chloramphenicol acetyltransferase gene (cat, a stuffer sequence). Upon cre-mediated excision of the cat gene, the modified allele expresses Notch1 in tissues where Cre is expressed. (J:108444)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:108444 Watanabe Y, et al., Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development. 2006 May;133(9):1625-34
• All: 4 reference(s)