Anpep^tm1Sid
Targeted Allele Detail

Summary

• Symbol: Anpep^tm1Sid
• Name: alanyl aminopeptidase, membrane; targeted mutation 1, Richard L Sidman
• MGI ID: MGI:3702506
• Synonyms: APN-, Lap1^tm1Sid
• Gene: Anpep Location: Chr7:79471551-79497958 bp, - strand Genetic Position: Chr7, 45.19 cM
• Alliance: Anpep^tm1Sid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 6 were replaced with an IRES-LacZ, floxed PGK-neo cassette. The null allele was confirmed by the absence of mRNA and protein in brain, kidney, spleen, liver, pancrease, intestine and ovary tissue as detected by RT-PCR and immunohistochemistry, respectively. (J:119474)

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anpep Mutation: 84 strains or lines available

References

• Original: J:119474 Rangel R, et al., Impaired angiogenesis in aminopeptidase N-null mice. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4588-93
• All: 3 reference(s)