Lhx6^tm1Vpa
Targeted Allele Detail

Summary

• Symbol: Lhx6^tm1Vpa
• Name: LIM homeobox protein 6; targeted mutation1, Vassilis Pachnis
• MGI ID: MGI:3702513
• Synonyms: Lhx6^tm1Pach, Lxh6^LacZins, Lxh6^nlacZ
• Gene: Lhx6 Location: Chr2:35971965-35995420 bp, - strand Genetic Position: Chr2, 24.17 cM
• Alliance: Lhx6^tm1Vpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119476
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: A vector including an IRES-LacZ and a floxed PGK-neo cassette was unexpectedly inserted at the 3' end of the gene resulting in minimal disruption of the coding sequence. Correct expression of the reporter relative to the endogenous protein was confirmed by beta-glactosidase assay and immunostaining brain sections with antibodies for Lhx6 and beta-galactosidase. QRT-PCR confirmed reduced transcript expression. This allele is hypomorphic. (J:119476, J:198547)

Expression

In Mice Carrying this Mutation:	89 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx6 Mutation: 27 strains or lines available

References

• Original: J:119476 Liodis P, et al., Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci. 2007 Mar 21;27(12):3078-89
• All: 3 reference(s)