Lhx6^tm2Vpa
Targeted Allele Detail

Summary

• Symbol: Lhx6^tm2Vpa
• Name: LIM homeobox protein 6; targeted mutation 2, Vassilis Pachnis
• MGI ID: MGI:3702518
• Synonyms: Lhx6^-, Lhx6^tm2Pach
• Gene: Lhx6 Location: Chr2:35971965-35995420 bp, - strand Genetic Position: Chr2, 24.17 cM
• Alliance: Lhx6^tm2Vpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119476
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 and part of exon 5 were replaced with an IRES-eGFP and a floxed PGK-neo cassette. The neo cassette was then removed in vivo by Cre-mediated recombination. Immunohistochemistry and western blot analysis confirmed near total loss of protein expression in homozygous mice. No GFP expression is seen in heterozygotes. (J:119476)

Expression

In Mice Carrying this Mutation:	46 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx6 Mutation: 27 strains or lines available

References

• Original: J:119476 Liodis P, et al., Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci. 2007 Mar 21;27(12):3078-89
• All: 6 reference(s)