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Ightm1.1Lnit
Targeted Allele Detail
Summary
Symbol: Ightm1.1Lnit
Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Lars Nitschke
MGI ID: MGI:3702524
Synonyms: DQ52-
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119484
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Deletion
  Ightm1.1Lnit involves 1 genes/genome features (Igh) View all
 
Mutation detailsThis allele contains a single loxP site in place of DQ52, following cre mediated deletion of a floxed neomycin resistance cassette and HSV-tk that had been inserted in place of DQ52 and all its flanking sequences. In addition, the targeting vector replaced a wild-type HindIII site between JH3 and JH4 with an EcoRV site. (J:119484)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:119484 Nitschke L, et al., Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage. J Immunol. 2001 Feb 15;166(4):2540-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory