Tcrb^tm1Slek
Targeted Allele Detail

Summary

• Symbol: Tcrb^tm1Slek
• Name: T cell receptor beta chain; targeted mutation 1, Barry P Sleckman
• MGI ID: MGI:3702573
• Synonyms: Jbeta1^omega
• Gene: Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119552
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The locus was interrupted by the replacement of the Dbeta2-Jbeta2 gene cluster with a loxP site. Gene segment rearrangements on this allele are restricted to the Dbeta1-Jbeta1 gene segment cluster, which contains one Dbeta (Dbeta1) and six Jbeta (Jbeta1.1-Jbeta1.6) gene segments. (J:119552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrb Mutation: 97 strains or lines available

References

• Original: J:119552 Bassing CH, et al., Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 2000 Jun 1;405(6786):583-6
• All: 5 reference(s)