Hoxa1^{tm4(Hoxb1)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxa1^{tm4(Hoxb1)Mrc}
• Name: homeobox A1; targeted mutation 4, Mario R Capecchi
• MGI ID: MGI:3702592
• Synonyms: Hoxa1^B1(g)
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^{tm4(Hoxb1)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119279
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The endogenous coding region was replaced by the homeo box B1 coding region. An IREStauGFP cassette was also inserted into the locus, as well as an inversely oriented ACN self-excising neo selection marker. (J:119279)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:119279 Tvrdik P, et al., Reversal of Hox1 gene subfunctionalization in the mouse. Dev Cell. 2006 Aug;11(2):239-50
• All: 2 reference(s)