Hoxa1^tm5Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm5Mrc
• Name: homeobox A1; targeted mutation 5, Mario R Capecchi
• MGI ID: MGI:3702593
• Synonyms: Hoxa1^ARE(g)
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm5Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119279
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The 107 bp homeo box B1 autoregulatory enhancer was inserted into the endogenous promoter. An IREStauGFP cassette was also inserted into the locus, as well as an inversely oriented ACN self-excising neo selection marker. (J:119279)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:119279 Tvrdik P, et al., Reversal of Hox1 gene subfunctionalization in the mouse. Dev Cell. 2006 Aug;11(2):239-50
• All: 1 reference(s)