Hoxb1^{tm8(Hoxa1)Mrc}
Targeted Allele Detail

Summary

• Symbol: Hoxb1^{tm8(Hoxa1)Mrc}
• Name: homeobox B1; targeted mutation 8, Mario R Capecchi
• MGI ID: MGI:3702595
• Synonyms: Hoxb1^A1(g)
• Gene: Hoxb1 Location: Chr11:96256578-96259082 bp, + strand Genetic Position: Chr11, 59.86 cM
• Alliance: Hoxb1^{tm8(Hoxa1)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119279
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The endogenous coding region was replaced by the homeo box A1 coding region. An IREStauGFP cassette was also inserted into the locus, as well as floxed neo cassette. The neo was subsequently removed by crossing with cre deleter mice. (J:119279)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb1 Mutation: 24 strains or lines available

References

• Original: J:119279 Tvrdik P, et al., Reversal of Hox1 gene subfunctionalization in the mouse. Dev Cell. 2006 Aug;11(2):239-50
• All: 1 reference(s)