Olfm1^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Olfm1^tm1.1Lex
• Name: olfactomedin 1; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:3702618
• Synonyms: Olfm1^-, pancortin^-
• Gene: Olfm1 Location: Chr2:28083105-28120748 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Olfm1^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118333
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons M2 and Y were deleted in vivo by cre-mediated recombination. Immunoblots for all 4 isoforms in adult cerebral cortex lysates confirmed the absence of protein. (J:118333)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Olfm1 Mutation: 25 strains or lines available

References

• Original: J:118333 Cheng A, et al., Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. J Neurosci. 2007 Feb 14;27(7):1519-28
• All: 4 reference(s)