Tg(Igk-Lta/Ltb)10Cys
Transgene Detail

Summary

• Symbol: Tg(Igk-Lta/Ltb)10Cys
• Name: transgene insertion 10, Jason G Cyster
• MGI ID: MGI:3702620
• Synonyms: kLTb10
• Transgene: Tg(Igk-Lta/Ltb)10Cys Location: unknown
• Alliance: Tg(Igk-Lta/Ltb)10Cys page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igk-Lta/Ltb)10Cys expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lta (MGI:104797)
  mouse	Ltb (MGI:104796)

• Mutation details: The mouse Lta gene was fused with the transmembrane domain of Ltb and inserted into a vector containing the mouse Ig kappa (Igk) promoter and enhancer elements. Mice generated have multiple copies of the transgene and express a membrane form of lymphotoxin alpha (LTa) under control of the kappa light chain enhancer and promoter. The LTa transgene is selectively expressed in B lymphocytes. (J:73100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Mice of this line are reported to be almost identical to mice of line 4 (Tg(Igk-Lta/Ltb)10Cys).

References

• Original: J:73100 Ngo VN, et al., Splenic T zone development is B cell dependent. J Exp Med. 2001 Dec 3;194(11):1649-60
• All: 2 reference(s)