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Del(16Dgcr2-Arvcf)1Ais
Targeted Allele Detail
Summary
Symbol: Del(16Dgcr2-Arvcf)1Ais
Name: deletion, Chr 16, Arthur I Skoultchi 1
MGI ID: MGI:3702630
Synonyms: Del1Ais
Gene: Del(16Dgcr2-Arvcf)1Ais  Location: Chr16:17658219-18225826 bp  Genetic Position: Chr16, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64380
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted
Mutations:    Intergenic deletion, Intragenic deletion
  Del(16Dgcr2-Arvcf)1Ais involves 31 genes/genome features (Gm26219, Gm26170, Gm15954 ...) View all
 
Mutation detailsThese mice were created by either breeding, or by targeting ES cells as follows. A targeting vector containing a PGK promoter, a loxP site and a neomycin resistance gene was inserted into the DiGeorge syndrome critical region gene 2, resulting in the loss of exons 4 and 5. These ES cells were additionally targeted with a vector containing two regions of the armadillo repeat gene deleted in velo-cardio-facial syndrome flanking a hygromycin resistance gene, a loxP site and a promoterless puromycin resistance gene. The insertion of this vector resulted in the loss of amino acids 83-276. Subsequent transient cre expression when the loxP sites were in cis resulted in the deletion of sequence between the two loxP sites. This 550-kb deletion encompasses 16 genes. (J:64380)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(16Dgcr2-Arvcf)1Ais Mutation:  0 strains or lines available
References
Original:  J:64380 Puech A, et al., Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10090-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory