Del(16Dgcr2-Arvcf)1Ais
Targeted Allele Detail
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Symbol: |
Del(16Dgcr2-Arvcf)1Ais |
Name: |
deletion, Chr 16, Arthur I Skoultchi 1 |
MGI ID: |
MGI:3702630 |
Synonyms: |
Del1Ais |
Gene: |
Del(16Dgcr2-Arvcf)1Ais Location: Chr16:17658219-18225826 bp Genetic Position: Chr16, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:64380
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Parent Cell Line: |
WW6 (ES Cell)
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Strain of Origin: |
STOCK 129/Sv and C57BL/6J and SJL
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Allele Type: |
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Targeted |
Mutations: |
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Intergenic deletion, Intragenic deletion
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Del(16Dgcr2-Arvcf)1Ais involves 31 genes/genome features (Gm26219, Gm26170, Gm15954 ...)
View all
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Mutation details: These mice were created by either breeding, or by targeting ES cells as follows. A targeting vector containing a PGK promoter, a loxP site and a neomycin resistance gene was inserted into the DiGeorge syndrome critical region gene 2, resulting in the loss of exons 4 and 5. These ES cells were additionally targeted with a vector containing two regions of the armadillo repeat gene deleted in velo-cardio-facial syndrome flanking a hygromycin resistance gene, a loxP site and a promoterless puromycin resistance gene. The insertion of this vector resulted in the loss of amino acids 83-276. Subsequent transient cre expression when the loxP sites were in cis resulted in the deletion of sequence between the two loxP sites. This 550-kb deletion encompasses 16 genes.
(J:64380)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(16Dgcr2-Arvcf)1Ais Mutation: |
0 strains or lines available
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Original: |
J:64380 Puech A, et al., Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10090-5 |
All: |
1 reference(s) |
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