Wwtr1^tm1Whun
Targeted Allele Detail

Summary

• Symbol: Wwtr1^tm1Whun
• Name: WW domain containing transcription regulator 1; targeted mutation 1, Walter Hunziker
• MGI ID: MGI:3702742
• Synonyms: Wwtr1^-
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^tm1Whun page

Gross anatomy of skeleton and renal histology of Wwtr1^tm1Whun/Wwtr1^tm1Whun mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119488
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a lacZ-neo cassette in frame into the second exon immediately downstream of the initiation ATG. Western blot failed to detect protein in mutant kidney samples, and lacZ expression was detected by X-gal staining. (J:119488)

Disease models

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

References

• Original: J:119488 Hossain Z, et al., Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1631-6
• All: 5 reference(s)