Pdx1^tm3Cvw
Targeted Allele Detail

Summary

• Symbol: Pdx1^tm3Cvw
• Name: pancreatic and duodenal homeobox 1; targeted mutation 3, Christopher VE Wright
• MGI ID: MGI:3702893
• Synonyms: Pdx1^{deltaI-II-III}
• Gene: Pdx1 Location: Chr5:147206907-147212658 bp, + strand Genetic Position: Chr5, 86.84 cM
• Alliance: Pdx1^tm3Cvw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104617
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph, Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: Area I-II-III, a conserved enhancer region, was removed by cre mediated recombination in the germline. This allele was shown to be a hypomorph. (J:104617)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdx1 Mutation: 35 strains or lines available

References

• Original: J:104617 Fujitani Y, et al., Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev. 2006 Jan 15;20(2):253-66
• All: 1 reference(s)