Nfkbid^tm1Ktak
Targeted Allele Detail

Summary

• Symbol: Nfkbid^tm1Ktak
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta; targeted mutation 1, Kiyoshi Takeda
• MGI ID: MGI:3702939
• Synonyms: IkappaBNS^-
• Gene: Nfkbid Location: Chr7:30121157-30128171 bp, + strand Genetic Position: Chr7, 17.52 cM
• Alliance: Nfkbid^tm1Ktak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113334
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette was inserted to replace a fragment containing exons 5-8. Northern blot confirmed inactivation of the locus. (J:113334)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkbid Mutation: 22 strains or lines available

References

• Original: J:113334 Kuwata H, et al., IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity. 2006 Jan;24(1):41-51
• All: 4 reference(s)