Por^tm2Ding
Targeted Allele Detail

Summary

• Symbol: Por^tm2Ding
• Name: cytochrome p450 oxidoreductase; targeted mutation 2, Xinxin Ding
• MGI ID: MGI:3703087
• Synonyms: Cpr^low
• Gene: Por Location: Chr5:135698894-135764180 bp, + strand Genetic Position: Chr5, 75.34 cM, cytoband G1
• Alliance: Por^tm2Ding page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119630
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: The insertion of a floxed neomycin resistance cassette into intron 15 resulted in hypomorphic expression of this allele. An additional loxP site was inserted into intron 2. (J:119630)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Por Mutation: 80 strains or lines available

References

• Original: J:119630 Wu L, et al., Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450. J Pharmacol Exp Ther. 2005 Jan;312(1):35-43
• All: 6 reference(s)