Smad2^tm1.1Epb
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1.1Epb
• Name: SMAD family member 2; targeted mutation 1.1, Erwin P Bottinger
• MGI ID: MGI:3703160
• Synonyms: Smad2^f
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1.1Epb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119642
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2, which contains the ATG, remained flanked by loxP sites following in vivo cre-mediated recombination by crossing floxed mice with cre mice. A floxed pgk-neomycin resistance cassette was removed from the locus. (J:119642)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:119642 Ju W, et al., Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol. 2006 Jan;26(2):654-67
• All: 22 reference(s)