Rictor^tm1.2Mgn
Targeted Allele Detail

Summary

• Symbol: Rictor^tm1.2Mgn
• Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.2, Mark A Magnuson
• MGI ID: MGI:3703322
• Synonyms: ric^Ex3del
• Gene: Rictor Location: Chr15:6737860-6829882 bp, + strand Genetic Position: Chr15, 3.25 cM, cytoband A1
• Alliance: Rictor^tm1.2Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119564
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Upon expression of cre recombinase in the germline, exon 3 was removed from the locus, leaving a loxP site and an frt site. Absence of protein was confirmed by Western blot analysis. (J:119564)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rictor Mutation: 141 strains or lines available

References

• Original: J:119564 Shiota C, et al., Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell. 2006 Oct;11(4):583-9
• All: 4 reference(s)