Tg(H2-K-AKR1B1)1Tj
Transgene Detail

Summary

• Symbol: Tg(H2-K-AKR1B1)1Tj
• Name: transgene insertion 1, University of Tokushima School of Medicine
• MGI ID: MGI:3703741
• Synonyms: hAR-Tg
• Transgene: Tg(H2-K-AKR1B1)1Tj Location: unknown
• Alliance: Tg(H2-K-AKR1B1)1Tj page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-AKR1B1)1Tj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AKR1B1 (231)

  Akr1b1

  (MGI:1353494)

• Mutation details: Expression of the full length human aldose reductase (AKR1B1) cDNA is under control of the murine H2-K^d promoter. Northern and Wester blotting shows expression of human aldose reductase mRNA and protein in all tissues tested. (J:120049)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Ldlr^tm1Her/Ldlr^tm1Her Tg(H2-K-AKR1B1)1Tj/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
cx2	Ldlr^tm1Her/Ldlr^+ Tg(H2-K-AKR1B1)1Tj/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
tg3	Tg(H2-K-AKR1B1)1Tj/0	involves: C57BL/6 * DBA/2

Phenotypes:

Affected Systems	cx1	cx2	tg3
show or hide all annotated terms
cardiovascular system	√	√	√
abnormal blood vessel morphology			√
increased susceptibility to atherosclerosis	√	√
hematopoietic system	√
abnormal macrophage physiology	√
homeostasis/metabolism	√	√	√
abnormal circulating cholesterol level	√
abnormal glucose homeostasis			√
hyperglycemia	√	√
abnormal enzyme/coenzyme activity			√
immune system	√
abnormal macrophage physiology	√
renal/urinary system			√
abnormal renal glomerular capsule morphology			√
vision/eye			√
cataract			√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:120049 Yamaoka T, et al., Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Diabetologia. 1995 Mar;38(3):255-61
• All: 12 reference(s)