Tg(H2-K-AKR1B1)1Tj
Transgene Detail

Summary

• Symbol: Tg(H2-K-AKR1B1)1Tj
• Name: transgene insertion 1, University of Tokushima School of Medicine
• MGI ID: MGI:3703741
• Synonyms: hAR-Tg
• Transgene: Tg(H2-K-AKR1B1)1Tj Location: unknown
• Alliance: Tg(H2-K-AKR1B1)1Tj page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-AKR1B1)1Tj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AKR1B1 (231)

  Akr1b1

  (MGI:1353494)

• Mutation details: Expression of the full length human aldose reductase (AKR1B1) cDNA is under control of the murine H2-K^d promoter. Northern and Wester blotting shows expression of human aldose reductase mRNA and protein in all tissues tested. (J:120049)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:120049 Yamaoka T, et al., Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Diabetologia. 1995 Mar;38(3):255-61
• All: 12 reference(s)