Tg(tetO-BMPR2*T504)1Jwst
Transgene Detail

Summary

• Symbol: Tg(tetO-BMPR2*T504)1Jwst
• Name: transgene insertion 1, James West
• MGI ID: MGI:3703793
• Synonyms: tetO7-BMPRII^delx+, TetO7-BMPRII^delx4+
• Transgene: Tg(tetO-BMPR2*T504)1Jwst Location: unknown
• Alliance: Tg(tetO-BMPR2*T504)1Jwst page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-BMPR2*T504)1Jwst expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BMPR2 (659)

  Bmpr2

  (MGI:1095407)

• Mutation details: Seven copies of the tetracycline responsive element and the CMV minimal promoter were used to drive the expression of a dominant-negative mutant BMPR2. The BMPR2 mutation is an insertion of a T at base 504 in the kinase (4th) domain of the protein, resulting in a premature stop 18 amino acids into the kinase domain. These transgenic mice were crossed to Tg(Tagln-rtTA)E1Jwst mice to obtain mice with inducible, muscle-specific expression of dominant-negative BMPR2. (J:98898)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:98898 West J, et al., Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res. 2004 Apr 30;94(8):1109-14
• All: 9 reference(s)