Wwox^tm1Ria
Targeted Allele Detail

Summary

• Symbol: Wwox^tm1Ria
• Name: WW domain-containing oxidoreductase; targeted mutation 1, Rami I Aqeilan
• MGI ID: MGI:3704944
• Synonyms: Wwox KO
• Gene: Wwox Location: Chr8:115166395-116079447 bp, + strand Genetic Position: Chr8, 60.99 cM, cytoband E1
• Alliance: Wwox^tm1Ria page

Tumor phenotype in Wwox^tm1Ria/Wwox^tm1Ria mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 6kb section containing exons 2-4 was replaced by a lacZ/neo cassette with a mouse intronic sequence, a splice acceptor site, and an IRES site. Western blot analysis confirmed the absence of the 46KDa protein and a beta-galactosidase assay confirmed lacZ expression. (J:120064)

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Wwox^tm1Ria

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwox Mutation: 59 strains or lines available

References

• Original: J:120064 Aqeilan RI, et al., Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3949-54
• All: 7 reference(s)