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FlnbGt(BGB085)Byg
Gene trapped Allele Detail
Summary
Symbol: FlnbGt(BGB085)Byg
Name: filamin, beta; gene trap BGB085, BayGenomics
MGI ID: MGI:3704947
Gene: Flnb  Location: Chr14:14518185-14651816 bp, - strand  Genetic Position: Chr14, 4.59 cM
Alliance: FlnbGt(BGB085)Byg page
Skeletal abnormalities in FlnbGt(BGB085)Byg/FlnbGt(BGB085)Byg mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  BGB085
Germline Transmission:  Earliest citation of germline transmission: J:120066
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsA BayGenomics gene trap vector (pGT1lxf) was inserted into intron 20 to create an in frame 5' fusion product with a lacZ cassette. The absence of the 250KDa protein was confirmed by western blot with an antibody recognizing the C-terminus end of Flnb. A beta-galactosidase assay confirmed expression of the lacZ fusion product. (J:120066)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flnb Mutation:  153 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:120066 Zhou X, et al., Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3919-24
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory