Bag6^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Bag6^tm1Pmc
• Name: BCL2-associated athanogene 6; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:3705047
• Synonyms: BAT3^-, Scythe^-
• Gene: Bag6 Location: Chr17:35354154-35366298 bp, + strand Genetic Position: Chr17, 18.59 cM
• Alliance: Bag6^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119857
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Almost the entire open reading frame was replaced with a neo cassette. The absence of the 130KDa protein was confirmed by western blot analysis of homozygous embryo fibroblasts. (J:119857)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bag6 Mutation: 40 strains or lines available

References

• Original: J:119857 Desmots F, et al., The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol Cell Biol. 2005 Dec;25(23):10329-37
• All: 4 reference(s)