About   Help   FAQ
Slc14a2tm1Suc
Targeted Allele Detail
Summary
Symbol: Slc14a2tm1Suc
Name: solute carrier family 14 (urea transporter), member 2; targeted mutation 1, Shinichi Uchida
MGI ID: MGI:3705080
Synonyms: UT-A2-
Gene: Slc14a2  Location: Chr18:78189363-78640157 bp, - strand  Genetic Position: Chr18, 52.53 cM
Alliance: Slc14a2tm1Suc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119860
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 4Kb genomic fragment including the promoter for isoform 2 and exon 13 was replaced by a neo cassette. The absence of the 50KDa protein was confirmed by western blot analysis of outer medulla tissue. (J:119860)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc14a2 Mutation:  53 strains or lines available
References
Original:  J:119860 Uchida S, et al., Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol. 2005 Aug;25(16):7357-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory