Slc14a2^tm1Suc
Targeted Allele Detail

Summary

• Symbol: Slc14a2^tm1Suc
• Name: solute carrier family 14 (urea transporter), member 2; targeted mutation 1, Shinichi Uchida
• MGI ID: MGI:3705080
• Synonyms: UT-A2^-
• Gene: Slc14a2 Location: Chr18:78189363-78640157 bp, - strand Genetic Position: Chr18, 52.53 cM
• Alliance: Slc14a2^tm1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119860
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4Kb genomic fragment including the promoter for isoform 2 and exon 13 was replaced by a neo cassette. The absence of the 50KDa protein was confirmed by western blot analysis of outer medulla tissue. (J:119860)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc14a2 Mutation: 53 strains or lines available

References

• Original: J:119860 Uchida S, et al., Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol. 2005 Aug;25(16):7357-63
• All: 1 reference(s)