Ignpq2^HIGA/Nsc
QTL Variant Detail

Summary

• QTL variant: Ignpq2^HIGA/Nsc
• Name: IgA nephropathy QTL 2; HIGA/Nsc
• MGI ID: MGI:3706156
• QTL: Ignpq2 Location: Chr4:150676733-150676858 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 81.43 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: HIGA/Nsc

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased serum IgA levels compared to BALB/cAJcl. (J:116904)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Ignpq2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:116904

Linkage analysis was performed using 244 animals from a (BALB/cAJcl x HIGA/Nsc)F2 intercross to identify QTLs associated with hyperserum IgA and glomerular IgA deposition. Parental strain HIGA is a mouse model of IgA nephropathy and displays high levels of serum IgA and glomerulonephritis with IgA deposits. F2 animals were phenotyped at 40 weeks of age and genotyped at 105 polymorphic loci.

Significant linkage to hyperserum IgA mapped to 66.5 cM on mouse Chromosome 2 and 79.3 cM on mouse Chromosome 4. The chromosome 2 locus is designated Ignpq1 (IgA nephropathy QTL 1) and is linked to D2Mit63 (LOD=5.01). The chromosome 4 locus is designated Ignpq2 and is linked to D4Mit33 (LOD=4.45). HIGA/Nsc-derived alleles at Ignpq1 and Ignpq2 confer increased serum IgA levels with an additive mode of inheritance.

Suggestive linkage to hyperserum IgA mapped to 40 cM on mouse Chromosome 1 near D1Mit215 (LOD=3.49). HIGA/Nsc-derived alleles at D1Mit215 confer increased serum IgA levels with an additive mode of inheritance.

Significant linkage to glomerular IgA deposition mapped to 53.5 cM mouse Chromosome 15 near D15Mit42 (LOD=4.4). This locus is named Ignpq3 (IgA nephropathy QTL 3). HIGA/Nsc-derived alleles at Ignpq3 confer increased glomerular IgA deposition with an additive mode of inheritance. Mgat3 at 46.2 cM is a potential candidate gene for Ignpq3; however, the Mgat3 coding sequence is identical between parental strain HIGA/Nsc and BALB/cAJcl.

References

• Original: J:116904 Nogaki F, et al., Chromosomal mapping of hyperserum IgA and glomerular IgA deposition in a high IgA (HIGA) strain of DdY mice. Kidney Int. 2005 Dec;68(6):2517-25
• All: 1 reference(s)