Brca1^tm1Aash
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1Aash
• Name: breast cancer 1, early onset; targeted mutation 1, Alan Ashworth
• MGI ID: MGI:3706167
• Synonyms: Brca1^F22-24
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1Aash page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119996
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 22-24 were replaced with a floxed sequence containing cDNA for exons 22-24 with an in frame myc epitope and a bovine growth hormone poly A sequence. This vector allows conditional excision of the second, terminal BRCT domain. Downstream of the floxed sequence, a splice acceptor and PGK-neo were inserted. (J:119996)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm1Aash

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:119996 McCarthy A, et al., A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol. 2007 Mar;211(4):389-98
• All: 21 reference(s)