Lzts1^tm1Cro
Targeted Allele Detail

Summary

• Symbol: Lzts1^tm1Cro
• Name: leucine zipper, putative tumor suppressor 1; targeted mutation 1, Carlo M Croce
• MGI ID: MGI:3706174
• Synonyms: Lzts1^-
• Gene: Lzts1 Location: Chr8:69585321-69636877 bp, - strand Genetic Position: Chr8, 33.88 cM
• Alliance: Lzts1^tm1Cro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' end of exon 1 was replaced with a neomycin resistance gene in the reverse orientation. Coding was interrupted 124 bp downstream of the first methionine. Western blot of mutant brain lysates confirmed absence of protein. (J:119989)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lzts1 Mutation: 23 strains or lines available

References

• Original: J:119989 Vecchione A, et al., Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 2007 Mar;11(3):275-89
• All: 2 reference(s)