Tusc2^tm1Avi
Targeted Allele Detail

Summary

• Symbol: Tusc2^tm1Avi
• Name: tumor suppressor 2, mitochondrial calcium regulator; targeted mutation 1, Alla Ivanova
• MGI ID: MGI:3706236
• Synonyms: Fus1^-
• Gene: Tusc2 Location: Chr9:107440454-107443307 bp, + strand Genetic Position: Chr9, 58.12 cM
• Alliance: Tusc2^tm1Avi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119985
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of the first exon, including the ATG, the entire second exon and part of the third exon. Northern blot confirmed absence of transcript in mutant brains. (J:119985)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tusc2 Mutation: 4 strains or lines available

References

• Original: J:119985 Ivanova AV, et al., Autoimmunity, spontaneous tumourigenesis, and IL-15 insufficiency in mice with a targeted disruption of the tumour suppressor gene Fus1. J Pathol. 2007 Apr;211(5):591-601
• All: 5 reference(s)