Trim54^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Trim54^tm1Eno
• Name: tripartite motif-containing 54; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3706252
• Synonyms: MuRF3^-
• Gene: Trim54 Location: Chr5:31274056-31294974 bp, + strand Genetic Position: Chr5, 17.06 cM, cytoband B1
• Alliance: Trim54^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120068
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neomycin cassette, resulting in the splicing of exon 3 to exon 5. The sequences encoding the first coiled-coil domain were removed from the locus. RT-PCR demonstrated that the mutation eliminated nearly all detectable mRNA downstream of the neo cassette. (J:120068)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim54 Mutation: 16 strains or lines available

References

• Original: J:120068 Fielitz J, et al., Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4377-82
• All: 3 reference(s)