Dlg3^tm1Grnt
Targeted Allele Detail

Summary

• Symbol: Dlg3^tm1Grnt
• Name: discs large MAGUK scaffold protein 3; targeted mutation 1, Seth G N Grant
• MGI ID: MGI:3706312
• Synonyms: SAP102^-
• Gene: Dlg3 Location: ChrX:99811328-99862016 bp, + strand Genetic Position: ChrX, 43.72 cM, cytoband C2
• Alliance: Dlg3^tm1Grnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120078
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-8 were replaced with a neomycin resistance cassette flanked by loxP sites. Integration of the targeting vector caused a frame shift. Absence of protein was confirmed by Western blot and immunohistochemistry. (J:120078)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg3 Mutation: 29 strains or lines available

References

• Original: J:120078 Cuthbert PC, et al., Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies. J Neurosci. 2007 Mar 7;27(10):2673-82
• All: 9 reference(s)