Ppargc1b^tm1.1Rev
Targeted Allele Detail

Summary

• Symbol: Ppargc1b^tm1.1Rev
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta; targeted mutation 1.1, Ronald M Evans
• MGI ID: MGI:3706314
• Synonyms: PGC-1beta^-
• Gene: Ppargc1b Location: Chr18:61431207-61533502 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Ppargc1b^tm1.1Rev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120079
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neo-tk cassette was inserted into intron 3. A third loxP site was inserted into intron 5. Transient cre expression removed the floxed sequence including the neo and exons 4 and 5. Northern blot confirmed absence of transcript in mutant heart, kidney and brown adipose tissue. (J:120079)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppargc1b Mutation: 57 strains or lines available

References

• Original: J:120079 Sonoda J, et al., PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5223-8
• All: 3 reference(s)