Abca3^tm1Frm
Targeted Allele Detail

Summary

• Symbol: Abca3^tm1Frm
• Name: ATP-binding cassette, sub-family A member 3; targeted mutation 1, Mason W Freeman
• MGI ID: MGI:3706347
• Gene: Abca3 Location: Chr17:24570997-24629178 bp, + strand Genetic Position: Chr17, 12.38 cM, cytoband A3.3
• Alliance: Abca3^tm1Frm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120296
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 are replaced with a zeo/neo cassette. The null allele was confirmed by the absence of protein in a western blot of homozygous embryonic tissue. (J:120296)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca3 Mutation: 92 strains or lines available

References

• Original: J:120296 Fitzgerald ML, et al., ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J Lipid Res. 2007 Mar;48(3):621-32
• All: 1 reference(s)