Nxph3^tm1.1Mami
Targeted Allele Detail

Summary

• Symbol: Nxph3^tm1.1Mami
• Name: neurexophilin 3; targeted mutation 1.1, Markus Missler
• MGI ID: MGI:3706428
• Gene: Nxph3 Location: Chr11:95400671-95405380 bp, - strand Genetic Position: Chr11, 59.01 cM, cytoband C
• Alliance: Nxph3^tm1.1Mami page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119861
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: In vivo cre mediated recombination removed all of exon 2. The absence of protein product was confirmed by western blot of tissue from homozygous mice, which showed antibody cross-reactivity to Nxph1, and from double homozygous mice lacking Nxph1 as well in which no protein band was detected. (J:119861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nxph3 Mutation: 14 strains or lines available

References

• Original: J:119861 Beglopoulos V, et al., Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol. 2005 Aug;25(16):7278-88
• All: 1 reference(s)