Cyp26c1^tm1.1Keya
Targeted Allele Detail

Summary

• Symbol: Cyp26c1^tm1.1Keya
• Name: cytochrome P450, family 26, subfamily c, polypeptide 1; targeted mutation 1.1, Kenta Yashiro
• MGI ID: MGI:3706550
• Gene: Cyp26c1 Location: Chr19:37674029-37681846 bp, + strand Genetic Position: Chr19, 32.36 cM
• Alliance: Cyp26c1^tm1.1Keya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119939
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A selection cassette containing a loxP site and frt flanked neomycin gene was inserted in intron 5. A second loxP site was inserted into the 3' untranslated region as well. Exon 6 was then deleted by cre-mediated excision of a floxed neo cassette. Excision was confirmed by PCR of genomic DNA. (J:119939)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp26c1 Mutation: 23 strains or lines available

References

• Original: J:119939 Uehara M, et al., CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Dev Biol. 2007 Feb 15;302(2):399-411
• All: 2 reference(s)