Rbl2^tm2Tyj
Targeted Allele Detail

Summary

• Symbol: Rbl2^tm2Tyj
• Name: RB transcriptional corepressor like 2; targeted mutation 2, Tyler Jacks
• MGI ID: MGI:3706581
• Synonyms: p130^2lox, p130^conditional, p130^lox
• Gene: Rbl2 Location: Chr8:91796685-91850472 bp, + strand Genetic Position: Chr8, 44.25 cM
• Alliance: Rbl2^tm2Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119919
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was used to introduce lox2722 sites on either side of exon 2, and place a hygromycin resistance cassette with a 3' loxP site in intron 2. Hygromycin was excised in vitro using Cre plasmid. (J:119919)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Rbl2^tm2Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rbl2 Mutation: 52 strains or lines available

References

• Original: J:119919 MacPherson D, et al., Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J. 2007 Feb 7;26(3):784-94
• All: 39 reference(s)