Rbl2^tm2.1Tyj
Targeted Allele Detail

Summary

• Symbol: Rbl2^tm2.1Tyj
• Name: RB transcriptional corepressor like 2; targeted mutation 2.1, Tyler Jacks
• MGI ID: MGI:3706582
• Synonyms: p130^-
• Gene: Rbl2 Location: Chr8:91796685-91850472 bp, + strand Genetic Position: Chr8, 44.25 cM
• Alliance: Rbl2^tm2.1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119919
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exon 2 was removed by cre-mediated recombination. (J:119919)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Rbl2^tm2.1Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbl2 Mutation: 52 strains or lines available

References

• Original: J:119919 MacPherson D, et al., Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J. 2007 Feb 7;26(3):784-94
• All: 10 reference(s)