Scmh1^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Scmh1^tm1Hko
• Name: Scm polycomb group homolog 1; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:3706668
• Gene: Scmh1 Location: Chr4:120262478-120387383 bp, + strand Genetic Position: Chr4, 56.52 cM, cytoband D1-D2
• Alliance: Scmh1^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119909
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exonic regions containing the SPM domain are replaced with a neo cassette. The absence of the 3.5Kb transcript was confirmed by northern blot analysis of homozygous testes; however, a small amount of truncated transcript is present. (J:119909)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scmh1 Mutation: 102 strains or lines available

References

• Original: J:119909 Takada Y, et al., Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development. 2007 Feb;134(3):579-90
• All: 1 reference(s)