Dbnl^{Gt(betageo)11Byg}
Gene trapped Allele Detail

Summary

• Symbol: Dbnl^{Gt(betageo)11Byg}
• Name: drebrin-like; gene trap 11, BayGenomics
• MGI ID: MGI:3706950
• Synonyms: Abp1^-
• Gene: Dbnl Location: Chr11:5738488-5750962 bp, + strand Genetic Position: Chr11, 3.87 cM
• Alliance: Dbnl^{Gt(betageo)11Byg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119847
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a betageo-IRES-PLAP-pA was inserted into intron 8 of the locus. A fusion protein consisting of exons 1-8 and the beta-geo was detected at low levels, and Western blot confirmed absence of wild-type protein in spleen and thymus. (J:119847)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dbnl Mutation: 27 strains or lines available

References

• Original: J:119847 Han J, et al., HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Mol Cell Biol. 2005 Aug;25(16):6869-78
• All: 3 reference(s)