Mmp13^tm1Jdar
Targeted Allele Detail

Summary

• Symbol: Mmp13^tm1Jdar
• Name: matrix metallopeptidase 13; targeted mutation 1, Jeanine D'Armiento
• MGI ID: MGI:3706953
• Synonyms: Mmp13^-
• Gene: Mmp13 Location: Chr9:7272514-7283331 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1-A2
• Alliance: Mmp13^tm1Jdar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120352
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Not Specified
• Mutation details: An EGFP (d2EGFP) and neomycin resistance cassette replaced exons 1 through 10. Western blot analysis confirmed the absence of protein expression in mouse embryonic cells. (J:197595)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp13 Mutation: 36 strains or lines available

References

• Original: J:120352 Kosaki N, et al., Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun. 2007 Mar 23;354(4):846-51
• All: 6 reference(s)