Mapk14^tm1.1Dvb
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1.1Dvb
• Name: mitogen-activated protein kinase 14; targeted mutation 1.1, Dmitry V Bulavin
• MGI ID: MGI:3706998
• Synonyms: p38^AF, p38alpha^ki
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1.1Dvb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120284
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Regulatory sites Thr180 and Tyr182 are replaced by alanine and phenylalanine, respectively. A floxed neo cassette inserted downstream of exon 8 was removed by germ line, cre mediated recombination. (J:120284, J:151980)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:120284 Shreeram S, et al., Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med. 2006 Dec 25;203(13):2793-9
• All: 10 reference(s)