A3galt2^tm1.1Hjg
Targeted Allele Detail

Summary

• Symbol: A3galt2^tm1.1Hjg
• Name: alpha 1,3-galactosyltransferase 2; targeted mutation 1.1, Hermann-Josef Grone
• MGI ID: MGI:3707000
• Synonyms: iGb3S^-
• Gene: A3galt2 Location: Chr4:128653051-128663091 bp, + strand Genetic Position: Chr4, 62.23 cM
• Alliance: A3galt2^tm1.1Hjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120323
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting construct was designed to remove the 5' portion of exon 5 by replacement with a floxed neomycin resistance gene and subsequent removal by cre recombinase in the germline. (J:120323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any A3galt2 Mutation: 19 strains or lines available

References

• Original: J:120323 Porubsky S, et al., Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5977-82
• All: 3 reference(s)