Cdh8^tm1Mta
Targeted Allele Detail

Summary

• Symbol: Cdh8^tm1Mta
• Name: cadherin 8; targeted mutation 1, Masatoshi Takeichi
• MGI ID: MGI:3707077
• Synonyms: Cad8^-, Cdh8^LacZ
• Gene: Cdh8 Location: Chr8:99751103-100143103 bp, - strand Genetic Position: Chr8, 49.4 cM
• Alliance: Cdh8^tm1Mta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120130
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the first 83 amino acids were replaced by a taulacZ or gaplacZ and floxed neo cassette into exon 2. The floxed neo was removed via cre mediated recombination. Western blot confirmed absence of protein in mutant spinal cord. (J:120130)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh8 Mutation: 53 strains or lines available

References

• Original: J:120130 Suzuki SC, et al., Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 2007 Mar 28;27(13):3466-76
• All: 5 reference(s)