Tcf12^tm2Zhu
Targeted Allele Detail

Summary

• Symbol: Tcf12^tm2Zhu
• Name: transcription factor 12; targeted mutation 2, Yuan Zhuang
• MGI ID: MGI:3707160
• Synonyms: HEB^bm
• Gene: Tcf12 Location: Chr9:71751534-72019611 bp, - strand Genetic Position: Chr9, 39.85 cM
• Alliance: Tcf12^tm2Zhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120411
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A series of point mutations were inserted into the basic DNA-binding region in exon 19 (coding exon 18), changing RLR to GHG (R611G, L612H, R613G). A floxed neomycin resistance gene was inserted into the locus and subsequently removed via transient cre expression. (J:120411)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf12 Mutation: 75 strains or lines available

References

• Original: J:120411 Barndt RJ, et al., Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol Cell Biol. 2000 Sep;20(18):6677-85
• All: 2 reference(s)