Cebpa^tm6Nerl
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm6Nerl
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 6, Claus Nerlov
• MGI ID: MGI:3707191
• Synonyms: TTS
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm6Nerl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120098
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• The GSK3 phosphorylation sites have been eliminated by changing T222, T226 and S230 to alanines. (J:120098)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 19 strains or lines available

References

• Original: J:120098 Pedersen TA, et al., Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J. 2007 Feb 21;26(4):1081-93
• All: 1 reference(s)