Hbtq^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hbtq^C57BL/6J
• Name: habituation QTL; C57BL/6J
• MGI ID: MGI:3707212
• QTL: Hbtq Location: Chr15:68160708-68160833 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 29.44 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased intersession habituation compared to DBA/2J. (J:119635)

Notes

Hbtq was identified in a male mouse population.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:119635

Linkage analysis was performed on 25 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains to identify QTLs associated with intersession habituation in mice. Approximately 19-26 male animals from each RI line were tested in a novel environment once a day over a period of 3 days. Males from parental strain DBA/2J display decreased exploratory behavior in a new environment whereas males from parental strain C57BL/6J display increased exploratory behavior.

A single locus on mouse Chromosome 15 between 32 cM and 46 cM is linked to habituation (LOD=8.8). This locus is named Hbtq (habituation QTL) and explains 80% of the genetic variance. Hbtq was confirmed in 72 males from a (C57BL/6J x DBA/2J)F2 intercross with linkage at D15Mit144 (p=0.0036). Homozygosity for C57BL/6J-derived alleles at Hbtq is associated with increased habituation. Eila3 (28 cM), Axtav, Axtofa5, Cocrb14 (39.6 cM), and Cocia2 (47 cM) are previously identified locomotor activity QTLs mapping near Hbtq.

References

• Original: J:119635 Bolivar V, et al., A region on chromosome 15 controls intersession habituation in mice. J Neurosci. 2003 Oct 15;23(28):9435-8
• All: 1 reference(s)