Sumf1^{Gt(RST760)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Sumf1^{Gt(RST760)Byg}
• Name: sulfatase modifying factor 1; gene trap RST760, BayGenomics
• MGI ID: MGI:3707232
• Synonyms: Sumf1^-
• Gene: Sumf1 Location: Chr6:108083989-108162543 bp, - strand Genetic Position: Chr6, 49.71 cM
• Alliance: Sumf1^{Gt(RST760)Byg} page

Appearance of Sumf1^{Gt(RST760)Byg}/Sumf1^{Gt(RST760)Byg} mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: RST760
• Germline Transmission: Earliest citation of germline transmission: J:120146
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0TMpfs Vector Type: secretory trap
• Mutation details: A gene trap vector was inserted into intron 3. RT-PCR demonstrated that the fusion transcript was composed by the first three exons of the locus and beta-geo. (J:120146)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RST760	CC326040 ; (MGI Seq Detail)	5' RACE	Chr6:108150316-108153028 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sumf1 Mutation: 33 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

ES cells used are CGR8 or E14TG2

References

• Original: J:120146 Settembre C, et al., Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4506-11
• All: 8 reference(s)