Cadps2^tm1Tfr
Targeted Allele Detail

Summary

• Symbol: Cadps2^tm1Tfr
• Name: Ca2+-dependent activator protein for secretion 2; targeted mutation 1, Teiichi Furuichi
• MGI ID: MGI:3707315
• Synonyms: Caps2^-, Caps2 KO
• Gene: Cadps2 Location: Chr6:23262772-23839420 bp, - strand Genetic Position: Chr6, 10.57 cM
• Alliance: Cadps2^tm1Tfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121256
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a pgk-neo cassette flanked by loxP sites. Western blot confirmed absence of protein in mutant cerebellum, neocortex and hippocampus. (J:120106, J:121256)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cadps2 Mutation: 86 strains or lines available

References

• Original: J:121256 Sadakata T, et al., Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest. 2007 Apr;117(4):931-43
• All: 15 reference(s)