Crmp1^tm1.1Swl
Targeted Allele Detail

Summary

• Symbol: Crmp1^tm1.1Swl
• Name: collapsin response mediator protein 1; targeted mutation 1.1, Shu-Wha Lin
• MGI ID: MGI:3707322
• Synonyms: Crmp1^-
• Gene: Crmp1 Location: Chr5:37399402-37449507 bp, + strand Genetic Position: Chr5, 19.96 cM
• Alliance: Crmp1^tm1.1Swl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120105
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A multi-step targeting process consisting of the insertion and subsequent removal of a floxed HPRT cassette into intron 5, and the insertion of a second floxed HPRT cassette into intron 3 resulted in the flanking of exons 4-5 with loxP sites. Transient cre expression ultimately excised both exons and the second HPRT cassette. Northern blot and Western blot confirmed absence of transcript and protein, respectively, in mutants. (J:120105)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crmp1 Mutation: 45 strains or lines available

References

• Original: J:120105 Su KY, et al., Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci. 2007 Mar 7;27(10):2513-24
• All: 2 reference(s)