Dedd^tm1Tmiy
Targeted Allele Detail

Summary

• Symbol: Dedd^tm1Tmiy
• Name: death effector domain-containing; targeted mutation 1, Toru Miyazaki
• MGI ID: MGI:3707325
• Synonyms: Dedd^-
• Gene: Dedd Location: Chr1:171156713-171169899 bp, + strand Genetic Position: Chr1, 79.34 cM, cytoband H2
• Alliance: Dedd^tm1Tmiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119734
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 1 and 2 with a neomycin resistance cassette. Northern blot confirmed absence of transcription in mutants. (J:119734)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dedd Mutation: 25 strains or lines available

References

• Original: J:119734 Arai S, et al., Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2289-94
• All: 4 reference(s)